E6: A titanium, magnetic levitation, artificial heart pump breakthrough, and much more

E6: A titanium, magnetic levitation, artificial heart pump breakthrough, and much more

Tony Morley, August 8th, 2024

Welcome to The Up Wing, Edition 6, the best in progress and optimistic news, collated, curated, and delivered weekly-ish. We report on the past, present, and future of human progress, progress studies, and optimistic news. We're pro-growth, free markets, classical liberalism, Enlightenment, science, technology, and a better future for all humanity. We're still in beta; hang in there.

86% of our subscribers are currently free subscriptions; please consider supporting our mission and newsletter here: Support The Up Wing

Help support the project by liking and sharing our Edition 6 post on X/Twitter


Breakthrough maglev, titanium, turbine heart pump successfully transplanted

A 58-year-old man just became the first person to receive a breakthrough, titanium, valveless heart pump from BiVACOR. The next-gen pump has a single magnetic levitation turbine, improved reliability, and enough "output for an adult male undergoing exercise."

"It’s hard for me to get perspective on what we’ve achieved," — ‘Can I get a soda?’ First words from historic artificial heart recipient

The culmination of more than 20 years of work by Daniel Timms and the team at BiVACOR — this new pump is the only one in the world to utilize magnetic levitation. A singular rotating turbine, magnetically suspended within the pump dramatically improves durability and output. The design, manufacture, and successful transplant represent a breakthrough technology in artificial heart life support.

Artificial hearts made from magnets and titanium could save many lives

"Artificial hearts made from magnets and titanium could save many lives" BBC, Science Focus

The Texas Heart Institute Implants BiVACOR® Total Artificial Heart
First-in-human novel valveless artificial heart implanted in a patient with end-stage heart failure as a bridge to heart transplant Houston, Texas, July 25, 2024 – The Texas Heart Institute (THI) and BiVACOR®, a clinical-stage medical device company, announced today the successful first-in-human implantation of the BiVACOR Total Artificial Heart (TAH)

The Texas Heart Institute Implants BiVACOR® Total Artificial Heart

Mortality rates have fallen across all ages, not just among infants and children

Over the last two hundred years, human mortality has fallen dramatically, not just in France, but globally — and while 0—5 child mortality has made the most dramatic progress. Globally the child mortality rate has plunged from roughly 40% circa 1800, to just 3.8% today.

With that being said, it's a common misconception that reductions in mortality have declined only among the youngest. This latest graph from Our World In Data shows how mortality has fallen across the full range of ages in France.

"When data collection began in 1816, around 1 in 5 babies in France died during infancy. Two centuries later, that figure was 1 in 274, a 50-fold reduction. In 1816, around 1 in 20 people aged 65, died. In 2021, it was 1 in 106, a five-fold reduction."
Death rates have declined across all ages, Saloni Dattani, Our World In Data

Now, with that being said, infant death rates have declined so dramatically over the same period as to be simply amazing. Every day of infancy is safer than in the past

Infant death rates have declined greatly over time. Saloni Dattani, Our World In Data

New Dual-Target Drug Could Make Antibiotic Resistance 100 Million Times Harder

"A team of scientists from the US and China has calculated that a new class of dual-action antibiotics could make it 100 million times more difficult for bacteria to evolve resistance."
New antibiotic nearly eliminates the chance of superbugs evolving
Researchers have combined the bacteria-killing actions of two classes of antibiotics into one, demonstrating that their new dual-action antibiotic could make bacterial resistance (almost) an impossibility.
New Dual-Target Drug Could Make Antibiotic Resistance 100 Million Times Harder
It’s easy to think of bacteria as one of the greatest scourges on Earth for the diseases and deaths they cause, and how they repeatedly thwart our best antibiotics, evolving into drug-resistant superbugs.

A new prototype vaccine could help cattle farming move the needle on climate change

A new prototype vaccine from US start-up ArkeaBio, cut cow methane emissions by 13 percent in a small trial, suggesting enormous potential to combat the climate impact of cattle farming. — Anti-methane vaccine could reduce the climate impact of livestock.

"Cows given the prototype vaccine produced 12.9 per cent less methane over a period of 105 days, according to results from a 2023 trial seen by New Scientist, with no adverse side effects or disruption to growth rates."
Anti-methane vaccine could reduce the huge climate impact of cow burps
A prototype vaccine from ArkeaBio, a US start-up, cut methane emissions by 13 per cent in a first trial involving 10 cows, offering a potential way to reduce the huge climate impact of cattle farming

A new AI powered ultrasound software deployed in Uganda is encouraging mothers to undertake early ultrasounds

"While ultrasound services are normal practice in many countries, software being tested in Uganda will allow a scan without the need for specialists, providing an incentive for pregnant women to visit health services early on"
“It has made pregnant mothers so interested in coming for ultrasound scans,” says Lukakamwa. “People are very much willing to join the study without any apprehension. Apparently, we are getting overwhelmed.”
‘I am happy to see how my baby is bouncing’: the AI transforming pregnancy scans in Africa
While ultrasound services are normal practice in many countries, software being tested in Uganda will allow a scan without the need for specialists, providing an incentive for pregnant women to visit health services early on

Global air pollution fatalities in children under five have fallen by more than 50% since 2000

"The report finds that while air pollution was the second largest risk factor of death for children under five in 2021, the death rate from air pollution for this group has decreased by 53% since 2000."

The results were driven in large part by a significant reduction in child death from indoor air pollution in China and South Asia, where the switch to cleaner indoor heating, cleaning, and cooking fuels has helped reduce the death rate from indoor air pollution in the greater region by 36%.

Air Pollution Deaths in Children Under 5 Down 53% Since 2000: Global Report
Researchers have published the State of Global Air (SoGA) 2024 report, which presents data on exposures to and health impacts of common air pollutants, including fine particulate matter (PM2.5), ozone (O3), and, for the first time, nitrogen dioxide (NO2), from 1990-2021. The report finds that while

Breakthrough study shows drug protected >2,000 young women with 100% effectiveness from contracting HIV

A breakthrough study published in The New England Journal of Medicine has shown that a twice-yearly injection of the antiviral drug Lenacapavir prevented >2,000 young women who received the injection from contracting HIV.

Stunning trial shows twice-yearly shots can prevent HIV infection
Injections of the drug lenacapavir protected sexually active women and girls in Africa from the virus.

Stunning trial shows twice-yearly shots can prevent HIV infection: Paywall Bypass

"Among 5338 participants who were initially HIV-negative, 55 incident HIV infections were observed: 0 infections among 2134 participants in the lenacapavir group (0 per 100 person-years; 95% confidence interval"

Root Source: Twice-Yearly Lenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women, The New England Journal of Medicine

A seventh person has been confirmed cured of HIV

"A 60-year-old man in Germany has become at least the seventh person with HIV to be announced free of the virus after receiving a stem-cell transplant." — Seventh patient ‘cured’ of HIV: why scientists are excited

"The case “broadens the horizon of what might be possible” for treating HIV," "Researchers are now trying to work out why these two transplants succeeded when others have failed."
Seventh Person ‘Cured’ of HIV after Stem Cell Transplant
A man in Germany is HIV-free after receiving stem cells that are not resistant to the virus

Humanity is closing in on the eradication of Guinea worm

Improved sanitation and drinking water access, along with a decades-long knowledge campaign on how to filter out the parasites have driven Guinea worm disease to the brink of eradication.

"Globally, Guinea worm has declined from an estimated 3.56 million cases across 20 countries in 1986 to just 14 human cases in 5 countries in 2023"
Even with no drug or vaccine, eradication of Guinea worm is in sight
Community-based efforts have reduced the parasitic infection to a handful of cases in humans each year, but the emergence of infections in dogs and other animals threatens to derail progress.

We're hoping to be more organized by Edition 10, currently Edition 6/10. We're still under construction, in beta mode, if you will [still a little 404 broken, with plenty of typos]. The site and newsletter will be updated in the following weeks. The UI/UX is going to get better; we have more great sections and content planned. Supporting with a modest donation helps enormously. Thank you kindly in advance.

The Up Wing Corporate

Want to get The Up Wing newsletter for your team? Help inspire and improve the well-being of your team by bringing The Up Wing to their inbox every week. Reach out to our team to help make it happen.

Copyright © 2024 The Up Wing, All rights reserved. The Up Wing is hosted, published, and dispatched by Ghost. If you enjoy our work, you can support The Up Wing with a premium subscription.

Read more